Clinical Trials at

Houston Mind & Brain

A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-arm Trial to Assess the Efficacy, Safety, and Tolerability of Centanafadine Extended-release Capsules as Monotherapy or as Adjunct to SSRI in Adult Subjects with Major Depressive Disorder.

Are you experiencing a low or depressed mood and a decreased interest in pleasurable activities? Do you have feelings of guilt or worthlessness, lack of energy, or poor concentration?


This research study is being conducted to assess the effectiveness, safety, and tolerability of centanafadine once-daily extended-release capsules for the possible treatment of adult participants with MDD who have reported inadequate response to at least 1 but no more than 3 treatments for depression in their current major depressive episode (MDE). This research study will test the hypothesis that centanafadine as monotherapy or in addition to SSRI (escitalopram) will lead to greater overall effectiveness in the possible treatment of MDD when compared to escitalopram alone or to placebo.


Click Therapeutics, Inc. / Study to Evaluate the Efficacy and Safety of a Digital Therapeutic as an Adjunct to Standard-of-Care Antipsychotic Therapy in Adult and Late Adolescent Participants with Experiential Negative Symptoms of Schizophrenia.

This study is researching 2 different mobile apps to see if they are safe and effective in helping people who have certain symptoms of schizophrenia. If you choose to participate, you will use 1 of the mobile applications on your personal smartphone.

For more information on either study, please fill out this form:

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